Ingredients
The research behind every ingredient
Each ingredient in Chhavique’s Pigment Reset was selected with care and backed by the studies linked below. Explore what the study looked at and the outcomes reported in the research.
3% TXA
Tranexamic acid has been studied for its role in improving the look of discoloration and supporting a more even-looking complexion. In this paper, topical TXA is discussed for hyperpigmentation-related concerns, with reported effects linked to pigmentation, inflammation, blood vessel activity, and skin barrier support.
What this study looked at
One study included in the review evaluated a serum containing 3% tranexamic acid, 1% kojic acid, and 5% niacinamide in 55 women with mild-to-moderate post-inflammatory hyperpigmentation over 12 weeks.
Outcomes
The paper reports a significant decrease in melanin index at Week 12 compared with baseline and the control group. The review also describes topical TXA as generally well tolerated, with few adverse reactions reported.
Study
5% Niacinamide
Niacinamide is a form of vitamin B3 that has been studied for visible concerns such as uneven tone, fine lines, redness, and elasticity. In this paper, niacinamide is described as the ingredient that most closely met the authors’ standards for penetration, mechanism, and clinical evidence.
What this study looked at
The paper discusses a randomized, double-blind, split-face, placebo-controlled trial in which 50 women applied 5% niacinamide and vehicle twice daily for 12 weeks.
Outcomes
According to the paper, 5% niacinamide showed significant improvement in fine lines and wrinkles, hyperpigmentation, red blotchiness, skin yellowing, and elasticity after 12 weeks. The review also reports 35% to 68% inhibition of melanosome transfer, which helps explain its effect on visible pigmentation.
Study
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Peptides
This section brings together the peptide studies for Acetyl Tetrapeptide-5, Palmitoyl Pentapeptide-4, and Palmitoyl Tripeptide-5. Across these papers, peptides are discussed in relation to visible wrinkle concerns, collagen-related pathways, and the appearance of the eye area.
What these studies looked at
One paper discusses an eye contour formulation containing acetyl tetrapeptide-5 and reports findings related to puffiness, dark circles, hydration, and elasticity around the eyes. Another study compared palmitoyl pentapeptide-4 cream with acetylhexapeptide-3 cream and placebo for crow’s feet over 8 weeks in 21 women. A separate review discusses palmitoyl tripeptide-5 as a signal peptide and outlines its proposed mechanisms.
Outcomes
In the eye contour study described in the peptide paper, dark circles improved by 10.7% and crow’s feet roughness improved by 19.2%, with good tolerability reported. The palmitoyl pentapeptide-4 trial reported better performance than acetylhexapeptide-3 and placebo for crow’s feet, along with stronger user satisfaction. For palmitoyl tripeptide-5, the review supports proposed collagen- and inflammation-related mechanisms, while also noting limited standalone clinical evidence in sensitive skin.
Studies
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Ceramides
Ceramides are skin-identical lipids that help support the skin barrier and hydration. In this study, a ceramide cream formulated to mimic the skin’s natural moisturizing systems was tested against reference moisturizers and placebo.
What this study looked at
The paper measured skin hydration at baseline and at 2, 4, 6, and 24 hours after a single application, and also measured transepidermal water loss over 24 hours. Safety was further assessed through repeat insult patch testing, ophthalmologist testing, and pediatric testing.
Outcomes
The study found that the ceramide cream significantly increased skin hydration over time and showed significantly greater hydration than all three reference moisturizers at 24 hours. It also significantly decreased transepidermal water loss over 24 hours and was reported to be non-sensitizing and non-irritating in the safety testing described in the paper.
Study
Squalane
Squalane is a stable derivative of squalene that was studied in this paper for its protective role against UVA-related cellular stress. The study explored how squalane affected human dermal fibroblasts exposed to UVA radiation.
What this study looked at
The paper tested squalane at concentrations of 0.005% to 0.015% in UVA-irradiated human dermal fibroblasts and evaluated cell viability, collagen-related activity, inflammatory markers, signaling pathways, and wound-healing behavior.
Outcomes
The study found that squalane helped counteract UVA-induced reduction in cell viability, supported prolidase activity related to collagen metabolism, reduced COX-2 expression close to control values at some tested concentrations, enhanced Nrf2 expression, and promoted fibroblast migration in the wound-healing model. The paper concludes that squalane showed protective potential in the context of UV-related cellular damage.
Study
Hyaluronic Acid
Hyaluronic acid is known for its ability to bind water and support skin hydration. In these papers, it is associated with improved hydration, skin barrier support, elasticity, and visible skin quality, especially when used topically or after aesthetic procedures.
What the studies found
The review on cellular effects shows that hyaluronic acid supports keratinocytes, fibroblasts, wound healing, and inflammation balance, with different effects depending on molecular weight. The topical HA review reports that it is well tolerated and can help improve hydration, fine lines, and overall skin rejuvenation.
Studies
Effects of hyaluronic acid on skin at the cellular level: a systematic review